Symbol
Name
ID

Nfe2l2
nuclear factor, erythroid derived 2, like 2
MGI:108420

Phenotype annotations related to immune system

Darker colors indicate more annotations

Human Phenotypes	Subacute progressive viral hepatitis
Disease(s) Associated with NFE2L2	Subacute progressive viral hepatitis
hepatocellular carcinoma

Mouse Phenotypes

increased splenocyte apoptosis

abnormal leukocyte adhesion

increased susceptibility to induced colitis

abnormal thymus morphology

enlarged thymus

enlarged spleen

increased spleen weight

decreased CD4-positive, alpha-beta T cell number

decreased T cell number

increased macrophage cell number

abnormal neutrophil physiology

increased IgG level

increased IgM level

abnormal macrophage physiology

abnormal splenocyte physiology

decreased circulating interleukin-1 beta level

increased circulating interleukin-1 beta level

increased circulating interleukin-6 level

increased circulating tumor necrosis factor level

abnormal lymph node morphology

enlarged lymph nodes

abnormal spleen physiology

decreased interleukin-1 beta secretion

decreased tumor necrosis factor secretion

increased susceptibility to experimental autoimmune uveoretinitis

increased anti-nuclear antigen antibody level

increased anti-double stranded DNA antibody level

increased acute inflammation

liver inflammation

glomerulonephritis

lung inflammation

Availability

Mouse Genotype

Nfe2l2^{em1(IMPC)Ccpcz}/Nfe2l2^{em1(IMPC)Ccpcz}

Nfe2l2^tm1Mym/Nfe2l2^tm1Mym

Nfe2l2^tm1Ywk/Nfe2l2^tm1Ywk

Nfe2l2^tm1.1Sred/Nfe2l2^tm1.1Sred
Tg(Scgb1a1-cre)1Grau/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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